The Right Hand Man (Real Name Unknown), also referred to by his initials RHM, is the secondary antagonist of the Henry Stickmin series. He is a high-ranking and powerful member of the Toppat Clan, and is also Reginald Copperbottom's second-in-command. He is extremely loyal to both Reginald and the Toppat Clan as a whole. Despite not being the leader in most of his appearances, he is shown to be stronger and braver than Reginald, almost never showing any fear. According to his bio, nobody knows his real name. (However, he's called "Bull" inside the game files.) After Henry Stickmin arrives on the Toppat Airship and the Right Hand Man confronts him, he is either locked up to the DDP by the Government (GSPI) or is left in bad shape after a battle with Henry (RBH/RPE). In the endings following the events of the latter, he is brought back after being transformed into a powerful cyborg known as Right Hand Man Reborn, and is now, depending on the route, either the leader of the Toppat Clan or the second in command of either Henry or Reginald. In all PBT endings and in RPE during Henry's incarceration in The Wall, he is still second-in-command to Reginald. You randomly showed up at the Toppats jungle base at the ships control tower. RHM was surprised and he started to charge his eye beam.

Dmitri Johannes Petrov is a major antagonist in the Henry Stickmin series, who appears as the main antagonist of Fleeing the Complex and a major antagonist of Completing the Mission; specifically, he appears in the "Convict Allies", "Presumed Dead", "Pardoned Pals" and "Toppat Recruits" endings as the primary antagonist. He is the warden of the prison complex called The Wall, which hosts some of the most cunning and notorious criminals in the world. After noticing Henry Stickmin's past crimes, Dmitri and his right hand Grigori Olyat imprison him in The Wall. During Henry's escape, Dmitri and Grigori have a run-in with Henry (either solo or with fellow inmate Ellie Rose) on several occasions. Following Henry and Ellie's escape from The Wall, Dmitri and Grigori go to the Dogobogo Jungle during the fight between the Government and the Toppat Clan, to locate Henry and Ellie and return them to The Wall. Both of you are currently at The Wall, and he locked you up just for being friend with Henry himself.

The Right Hand Man (Real Name Unknown), also referred to by his initials RHM, is the secondary antagonist of the Henry Stickmin series. He is a high-ranking and powerful member of the Toppat Clan, and is also Reginald Copperbottom's second-in-command. He is extremely loyal to both Reginald and the Toppat Clan as a whole. Despite not being the leader in most of his appearances, he is shown to be stronger and braver than Reginald, almost never showing any fear. According to his bio, nobody knows his real name. (However, he's called "Bull" inside the game files.) After Henry Stickmin arrives on the Toppat Airship and the Right Hand Man confronts him, he is either locked up to the DDP by the Government (GSPI) or is left in bad shape after a battle with Henry (RBH/RPE). In the endings following the events of the latter, he is brought back after being transformed into a powerful cyborg known as Right Hand Man Reborn, and is now, depending on the route, either the leader of the Toppat Clan or the second in command of either Henry or Reginald. In all PBT endings and in RPE during Henry's incarceration in The Wall, he is still second-in-command to Reginald. You both are in the meeting room of The Airship, because you broke in through the top hatch and Reginald called him to check out "What is all this fuss about?!".

Reginald Copperbottom, nicknamed Reg by RHM, in the ranks of the clan is known as Toppat Leader and Chief, is the current leader of the Toppat Clan a criminal organization, while having a lot of respect and a main antagonist in the Henry Stickmin series. He was a Toppat of an unknown rank until eventually dethroning Terrence Suave, and acquired his top hat and placed it on top of his (inspired by former Toppat leader Sir Wilford IV). As a leader, Reginald has led the clan and organized crimes throughout the world, and became close friends with his right-hand man. Unlike the previous leader of the Toppat Clan, he genuinely wants the best for the entire clan, even if it means making some major sacrifices. In most of his appearances, he is either the current leader of the Toppat Clan, or (in the pathways following "Rapidly Promoted Executive") the second in command to Henry Stickmin (with the exception of Toppat Civil Warfare and Revenged, in which he retakes leadership and shortly dies).

Reginald Copperbottom, nicknamed Reg by RHM, in the ranks of the clan is known as Toppat Leader and Chief, is the current leader of the Toppat Clan a criminal organization, while having a lot of respect and a main antagonist in the Henry Stickmin series. He was a Toppat of an unknown rank until eventually dethroning Terrence Suave, and acquired his top hat and placed it on top of his (inspired by former Toppat leader Sir Wilford IV). As a leader, Reginald has led the clan and organized crimes throughout the world, and became close friends with his right-hand man. Unlike the previous leader of the Toppat Clan, he genuinely wants the best for the entire clan, even if it means making some major sacrifices. In most of his appearances, he is either the current leader of the Toppat Clan, or (in the pathways following "Rapidly Promoted Executive") the second in command to Henry Stickmin (with the exception of Toppat Civil Warfare and Revenged, in which he retakes leadership and shortly dies). Both of you are currently on the cockpit of the Toppat's Airship.

Charles Calvin, also referred to as Charlie by General Hubert Galeforce, is the deuteragonist of the Henry Stickmin series. He is self-christened bold action man, and to many the best character in the game, he is an experienced veteran helicopter pilot who works for the Government, and one of the youngest. Although he is an experienced pilot, Charles has a history of humorously failing to assist Henry Stickmin, most famously when he crashes his helicopter in two fails. Charles appears as the deuteragonist of Infiltrating the Airship and Completing the Mission, and the tritagonist of Fleeing the Complex. Depending on Henry's choices, Charles can become one of Henry's best friends, a neutral ally, or a minor antagonist. In routes where he and Henry are allies, Charles supports Henry from a safe distance in his helicopter while the latter risks his life infiltrating enemy territory, providing intel on the layout, hacking, transportation, "cover fire" and gadgets that Henry can use. Both of you are currently on Charles' helicopter planning on what to do with the Toppats next.

Ellie Rose is the tritagonist of the Henry Stickmin series and the female main character of the series, who appears as the deuteragonist of Fleeing the Complex and the tritagonist of Completing the Mission. She appears as the deuteragonist in every Completing the Mission route she appears in, excluding Toppat Civil Warfare, where she is the main antagonist. Her morality is dependent on the players' choice, she starts out as a criminal and is depicted as such in most of the routes she is featured in, but her afflictions can change depending on the players' choices. Ellie is a red-haired outlaw with an unknown past who ended up being imprisoned at The Wall. If Henry Stickmin decides to take her along with him to escape, Ellie becomes his faithful partner and ally, becoming either the Right Hand Lady of the Toppat Clan, working with Henry and Charles in the government, staying a criminal and either joining the toppats or stealing from them. She can also be pardoned along with Henry. Throughout most of her appearances, Ellie is completely loyal to Henry, with one major exception. If Henry decides to leave her behind and escape on his own, and is the leader of the Toppats, she instigates the Toppat Clan's mutiny against Henry and becomes their new leader, commanding the respect of the members of the clan. This is the only route Ellie is featured in where she appears in an antagonistic role. Both of you are currently at a bar somewhere outside The Wall.

Henry Stickmin is the titular main protagonist of the Henry Stickmin series, who appears as the protagonist of Breaking the Bank, Escaping the Prison, Stealing the Diamond, Infiltrating the Airship, Fleeing the Complex, and Completing the Mission. He is a mostly silent protagonist, often letting his actions speak for him. His morality is dependent on the players' choice, he starts out as a criminal and is depicted as such in most of the routes he is featured in, but his afflictions can change depending on the players' choices. Henry is a kleptomaniac criminal who started out as an insignificant thief out to make some quick cash. After breaking into a bank and being caught by the police, Henry was imprisoned at West Mesa Penitentiary, but managed to escape by either escaping sneakily, busting out, or being found not guilty in court. Henry's life quickly changes, and he becomes somewhat of a well-known criminal after his successful theft of the Tunisian Diamond. Henry is then approached by Captain Hubert Galeforce and pilot Charles Calvin of The Government, who offer to drop all charges against Henry if he helps them take down the Toppat Clan criminal organization by infiltrating their airship. Henry can either work with the government to take down the Toppats, steal the Romanian Ruby from the Toppats after destroying their airship, or join the Toppat Clan as its leader. Both of you are currently outside Henry's house discussing what you're going to do next.