To make Christmas lights twinkle, you can simply plug them into a wall socket and they will twinkle automatically. If you want to make them twinkle in a specific way, you can use a controller to change the settings or connect them to a Christmas light show software. You can also use a circuit board and some wires to create a custom pattern of twinkling lights. You can find many tutorials online on how to make Christmas lights twinkle in various ways.