Yes, CVS is closed on Christmas Day. The stores are typically closed on major holidays like Christmas, Easter, Thanksgiving, and New Year's Day. This allows the staff to spend time with their families and enjoy the holidays. If you need medication or other items from CVS on Christmas Day, you should plan ahead and stock up before the holiday. You can also check with your local CVS to see if they offer any special holiday hours or have an online store that's open 24/7.