The CVS stores will be closed on Christmas Day, but many locations will remain open until 6 pm on Christmas Eve. Some CVS locations may have extended hours, so it's best to check the store's holiday hours before heading out. CVS will also be closed on New Year's Day and will reopen on January 2nd. If you need medical supplies or other essential items on Christmas Day, you can still find nearby stores that may be open, such as Walgreens, Rite Aid, or Walmart.