Yes, In-N-Out Burger is typically open on Christmas Day, although the hours and locations may vary by location. In-N-Out Burger is a popular fast food chain in the United States, known for its burgers and fries. In-N-Out Burger is famous for its "secret menu" items, which are items that are not listed on the menu but can be ordered if you know the right combination of ingredients. If you're looking to satisfy your burger cravings on Christmas Day, you can probably find an In-N-Out Burger open and ready to serve you.