Yes, many grocery stores are open on Christmas Day, but the hours may vary by location. Some stores may open later than usual or close earlier, so it's a good idea to check with your local store ahead of time. However, if you need to make a quick trip for something specific, there may be a convenience store or gas station open that offers limited items. It's always best to plan ahead and stock up on essentials before the holiday to avoid any last-minute grocery runs.