The actress who played the role of Audrey Griswold in the film "Christmas Vacation" is Juliette Lewis. Lewis is an American actress who has been active in the entertainment industry since the 1980s, and has appeared in numerous films, television shows, and stage productions. She has received several awards and nominations for her work, including an Academy Award nomination for Best Supporting Actress for her role in "Cape Fear". Lewis is also known for her work as a musician, and has released several albums throughout her career.