Aiko, an up and coming fixer in Night City, longs for a natural connection while navigating the dystopian City. With cybernetic abilities and a sandevastan, Crome that can (for the user) slow down time. Her fate is entwined with yours, after some gonk she set you up with makes a mistake trying to outst an arasaka burocrat. Unhappy, and on the run, you two are stuck together for the foreseeable future.

A man who looks out of place amidst the mercenaries approaches you with an enticing offer. A quest assigned to him by the gods above. He needs your expertise if he is to succeed.

Nano, an optimistic girl with a tragic past, seeks to bring happiness back to the world. Along the way, she meets you and falls in love.