Known to be the last Vampire in Nosgoth that caused the collapse of the Pillars at the end of Blood Omen by refusing the sacrifice, Kain sets out to begin his conquest of Nosgoth. Unable to yet create Vampires of his own, he was assisted by the mysteriously resurrected vampire known as Vorador, who allied himself with Kain and agreed to assist in the revival of the Vampire race, personally siring the first of a new race of vampires which would make up the soldiers of Kain's vampire army.

Umah is a vampire lieutenant of the Cabal, the vampire resistance in Meridian. She acts as both a guide and friend to the vampire lord known as Kain. Umah eventually becomes a potential love interest for Kain, yet in the end she turns traitor for Kain in favor of her position with the Cabal. Vorador took care of Umah and became her mentor. Umah saw Vorador as both her mentor and viewed him as a father figure to her from how much they respected each other. Meanwhile Vorador was the first human transformed into a vampire by Janos Audron who is one of the Ancient Vampires from Nosgoth's older history.

Ariel's specter was bound to the Pillars of Nosgoth, in which she has haunted them for many centuries afterward. As the Guardian of Balance, Ariel is one guardian out of eight other guardians from the Circle of Nine. Her spirit remains trapped in guarding Nosgoth's Pillars since the day of their corruption. Ariel was born to serve the Pillars as Guardian of Balance at some point in the centuries of Nosgoth's early history along with the immortality gifted to her role. Ariel's magic influenced the regulation of the other magic in Nosgoth and her magical prowess was only rivaled by that of her beauty. At some point, Ariel became romantically involved with a fellow guardian known as Nupraptor, who is the Guardian of the Mind pillar. The two embarked on a controversial relationship, of which the other seven guardians may have disapproved of. Nupraptor went insane when he was first to discover Ariel was no longer of this world due to the Hylden Lord possessing Mortanius to get rid of Ariel.

Reala's signature colors are red and black. In the original Saturn game Reala had a purple ruffled collar, yellow claw-like talons for fingers and a vest that appears to be open with a diamond patterned chest. He also has a red and black-striped jester's hat that is, presumably, a part of his body and not, in fact, a hat. Reala was redesigned for "NiGHTS: Journey of Dreams"; sporting a mask called a Persona, a symbol of loyalty to Wizeman. It is gold with a pink jewel in the center with black feathers on the edges. His vest is closed over his chest and has a flame/swirl pattern. He wears red arm guards and hip-plates, which both have a flame-like design on them and gold trim. He also wears dark brown fingerless gloves and dark brown bandages on his wrists. As in the original game, his signature colors are red and black. His boots are mostly dark red, with some bright red flame patterns and a single bright red stripe interspaced in the middle of the boots. Although he keeps his red jester's hat from the original game "NiGHTS into Dreams", it now has dark red stripes instead of black stripes; it also appears to be slightly less sharply angled than the first game. Reala also wears dark brown bandages on his legs, although they are mostly concealed by his boots. He also, for some reason, has pale pink nails and a pink ruff on his neck.

David Leatherhoff is the protagonist of "Afraid of Monsters" and "Afraid of Monsters: Director's Cut", as well as providing a cameo appearance in a joke ending for "Cry of Fear" where he meets Simon Henriksson by accident.

Simon Henriksson, or simply known as Simon, is the protagonist of "Cry of Fear".

The Sorrow was the "Spirit Medium Soldier" of the Cobra Unit. Although he had no actual unique combat abilities like the other Cobras, The Sorrow was gifted with the powers of a medium. He was able to summon the dead and assume their combat abilities by bringing their spirits into himself. Communicating with dead soldiers also gave him several advantages during a battle, such as learning of enemy positions. Like the other Cobras, his codename reflected the emotion he brought to the battlefield.

Megatron from Cyberworld is a bold reinterpretation of the classic Decepticon leader—thrust into a digital gauntlet, donning new forms (bull and tank), and voiced with fresh energy. It’s a character that blends familiar ruthlessness with unexpected team-ups in a high‑stakes, virtual game world.

Monsoon (季節風) was a Cambodian mercenary and cyborg ninja and a member of Desperado Enforcement LLC. He was one of the Winds of Destruction alongside Sundowner and Mistral, and was named after the seasonal wind systems that occur in West Africa and Asia-Australia.

Another wild encounter with a Brute, better known as a Jiralhanae.

A wild encounter with a Jiralhanae.

Shuji Shimada (嶋田 習次 , Shimada Shūji) is the first enemy encountered in "Siren: Blood Curse". He also acts as one of the game’s secondary antagonists. He is a police sergeant with a bizarre gait. The Shibito can mimic human behavior, capable of speech and are not easy to stop with doors or windows, capable of functioning as though their reanimated bodies were not possessed.

Pegasus J. Crawford, also known as Maximillion Pegasus, is the president of Industrial Illusions and the creator of the game of Duel Monsters. Pegasus owns many cards that have never been released to the public. He originally wanted to be an artist before becoming obsessed with Egypt and creating Duel Monsters. This did serve to fulfill his original dream as he drew monsters for his game.

Yami Bakura, also known as Dark Bakura, is the evil spirit of the Millennium Ring, and the main antagonist of the original "Yu-Gi-Oh!" series. Yami Bakura appears as a recurring secondary antagonist for most of the series, until the final arc where he is the main antagonist. Through the Millennium Ring, Bakura Ryou became a host to the spirit, allowing Yami Bakura to possess Bakura; even able to mimic his host's personality almost perfectly to the point that he is able to fool Bakura's friends. Yami Bakura is the longest running and most prominent adversary in the entire series, being an antagonistic counterpart and a great adversary to Yami Yugi.

Mai Valentine, also known as Mai Kujaku in the manga and Japanese anime, is a recurring and supporting character in the "Yu-Gi-Oh!" manga and anime.

Thrax is the main antagonist of Osmosis Jones. Thrax is a virus-like humanoid with red skin and long purple tentacle-like "hair" resembling dreadlocks. He has dull, crooked teeth and yellow eyes with dark yellow sclera. His hands have dark red nails, his index finger on his left hand glows orange when he touches something. He dons a black trench coat over a gray turtleneck shirt, black pants and matching shoes.

Seto Kaiba is one of the main characters of the "Yu-Gi-Oh!" anime. He is the older brother of Mokuba and the modern-day reincarnation of Priest Seto himself, the original keeper of the Blue-Eyes White Dragon. The arch-rival to Yugi Mutou.

Yami Marik is the secondary antagonist of the "Yu-Gi-Oh!" original series, serving as the overarching antagonist in the Battle City arc in the manga, as well as the main antagonist in the Tournament Finals arc and seasons two and three of the anime series "Yu-Gi-Oh! Duel Monsters". Yami is the darker, alternate personality of Marik Ishtar and is dangerous with a penchant for wanting to toy with individuals who challenge him to a duel.

This design of Soundwave is loosely based upon the "Transformers: Prime" continuity of the Transformers multiverse.

Val is an antagonist in "Outlast 2". Val is the leader of a splinter group from the Testament of the New Ezekiel, called the Heretics.

A dark creature of the night, isolated from many... yet Amdis had not expected the arrival of company. Enter his lair if you dare.

Janos Audron is a recurring supporting character in the Legacy of Kain series, with major roles in "Soul Reaver 2", "Blood Omen 2" and "Legacy of Kain: Defiance".

Vorador is a major supporting character throughout the Legacy of Kain series, appearing in every title aside from "Legacy of Kain: Soul Reaver". A long-lived, decadent and abrasive vampire, he acted as something of a mentor to Kain following his transformation, and was considered the paragon of all his kindred by the events of Blood Omen. Fiercely loyal to his people, Vorador viewed humanity with contempt, and his exploits against the Sarafan and the Circle of Nine became legendary over several centuries.