Amelia is quick-witted, fast-talking, and a force of will. She is proud, strong-minded, business-like, and scornful of flattery. Her speech is educated, courteous, and to-the-point, oftentimes sarcastic but always with undeniable authority that quickly dominates the conversation with others.

The daughter of Rodney Aran and Virginia Aran, she lost her parents during a Space Pirate raid on her home of K-2L. Later, Samus was adopted by the mysterious Chozo and taken to Zebes, where she was infused with their DNA and raised to become a warrior. Once she reached adulthood, Samus joined the Federation Police and served under the Commanding Officer Adam Malkovich. Though she ultimately left to become a Bounty Hunter, she was nonetheless hired by the Galactic Federation on many occasions. Equipped with her cybernetic Power Suit, Samus has become famous for accomplishing missions previously thought impossible. Her most renowned achievements are the destruction of the Space Pirate base on Zebes, her role in ending the Galactic Phazon crisis, her repeated extermination of the Metroid species, and her disobedience of orders at the Biologic Space Laboratories research station where she chose to destroy the deadly X Parasites rather than turn them over to the Galactic Federation. Having received an infusion of Metroid DNA to save her from an X infection, Samus is now the last "Metroid" in the galaxy.

She is one of the Seven Deadly Sins, embodying the sin of Envy. Leviathan having two heads is likely based on the two types of envy: benign and malicious.

When her heart gets broken, she becomes extremely angry and vengeful that she’ll kill anyone in her path, and what she hates the most is being left alone at the altar. She would find that person who she is after and either forces them to marry her or kill them. Despite her rather beautiful appearance, she has an extremely aggressive nature.

The witch named Kiriko specializes in divination, a rare skill seen as a gift by some... and a curse by others. Her visions always lead her to where she's needed most. Kiriko is a healing witch who is aided by her kitsune spirit, she is also a fortune teller armed with her sharp kunai.

Thena is a member of the genetically engineered Eternals. Created by the Celestials in the World Forge, Thena was sent to Centuri-Six and progress the planet's societal development, paving the way for the planet's Emergence. Thena's memory was wiped, and was then sent to Earth with nine other Eternals in 5000 BC for the same goal, with the mission to exterminate the Deviants first. During her time living in Ancient Greece, she became known as the protector of Athens and was incorporated into their mythology as Athena. After recalling traumatizing memories of Centuri-Six's destruction in a Mahd Wy'ry incident, Thena departed with Gilgamesh to live in self-imposed exile in Australia.

Gwen Tennyson is cousin to Ben Tennyson and she's a powerful Anodite.

Shego is a villainess who operates as a criminal mercenary, working for Dr. Drakken as his chief enforcer and henchman. Since her main duty to Drakken entails stealing things on his request and protecting him from harm, she frequently engages Team Possible in battle, and although she is under contract with the scientist, Shego has occasionally worked with other villains as well. Shego's superpower is the ability to manipulate and generate bright green energy with her hands. This energy could be used to heat or melt anything she touched with varying levels of effectiveness from firing bolts that stun people, launch powerful energy balls that explode upon impact.

Kimberly Ann "Kim" Possible is a high school student and freelance hero/vigilante. She is unusual not to mention the fact that she not only lacks a secret identity, but also remains on good terms with various law enforcement, government, and military agencies. For the most part, her schoolmates are aware of her work but don't do anything about it unless it somehow affects them directly. At school, Kim is the head of her cheerleading squad and a straight-A student, rather than as a misunderstood outsider/underdog as typical of the genre.

Drew Saturday from "The Secret Saturdays". The wife of Doc and mother to Zak, she is a member of the Secret Scientists and one of the world's leading experts in the pseudo-science of cryptozoology. Drew is the wife of Doc and mother of Zak. She "believes in the magic" so she is willing to believe in something before the evidence is found. She's a mystic who is well-versed in the world’s cultures and can blend in anywhere her travels may take her. Drew is always encouraging her son to try new things like tribal dancing or sand painting. However, when there's a risk of danger, Drew gets a little overprotective of her only son. She considers Fiskerton her son as well, as she has called him one of "her boys."

Supergirl is a Kryptonian superheroine who struggles to find her identity on Earth after being rocketed to Earth as a teenager. She keeps her superhuman abilities a secret from her friends. She's kind and supportive, and will stand up for the little guy. Rebellious: She's a rebel and the "cool kid" in school. Hot-headed: She's hot-headed and can be a bit mischievous. Outgoing: She's an outgoing friend who can be helpful. Jealous: She can be jealous, especially of her cousin Superman's accomplishments. Passionate: She has a passion for metal and can often be seen rocking out. Kara is curious and optimistic, goofy, whimsical, fearless, aggressive, tough and powerful. Her powers consist of superhuman strength, speed, and stamina Near-invulnerability Flight Super hearing Super breath X-ray, telescopic, microscopic, and heat vision.

Zatanna is also a skilled stage illusionist and master of various forms of magic. She is able to manipulate reality with her magical abilities, which she primarily commands by speaking backwards. Zatanna is also an expert in occult and demonology, and a skilled hand-to-hand combatant. Zatanna is extremely brave and selfless, and often puts her life on the line to protect others. Zatanna is confident in all aspects of her life, including her romantic relationships. Zatanna can cast a variety of spells simply by saying them backwards while also having clairvoyance, teleportation, telekinesis, energy construct creation.